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BENZETIMIDE

BENZETIMIDE Structure
BENZETIMIDE structure
CAS No.
21888-98-2
Chemical Name:
BENZETIMIDE
Synonyms
R 16470;BENZETIMIDE;Dexbenzetimide;DEXETIMIDE HCL;(+)-Benzetimide;RSYYBENZETIMIDE;Dextrobenzetimide;(S)-(+)-Dexetimide;BENZETIMIDE USP/EP/BP;(+)-DEXETIMIDE HYDROCHLORIDE
CBNumber:
CB6343451
Molecular Formula:
C23H26N2O2
Molecular Weight:
362.46
MDL Number:
MFCD00242706
MOL File:
21888-98-2.mol
Last updated:2023-07-12 16:37:22
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BENZETIMIDE Properties

Melting point 181-183°
alpha D20 +125° (chloroform)
Boiling point 543.9±50.0 °C(Predicted)
Density 1.178±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 100 mg/mL (275.89 mM)
pka 11.20±0.40(Predicted)
FDA UNII 43477QYX3D

SAFETY

Risk and Safety Statements

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

BENZETIMIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0026226 Dexetimide 99.20% 21888-98-2 10mg $90 2021-12-16 Buy
ChemScene CS-0026226 Dexetimide 99.20% 21888-98-2 50mg $210 2021-12-16 Buy
American Custom Chemicals Corporation API0006654 DEXETIMIDE 95.00% 21888-98-2 5MG $504.38 2021-12-16 Buy
Product number Packaging Price Buy
CS-0026226 10mg $90 Buy
CS-0026226 50mg $210 Buy
API0006654 5MG $504.38 Buy

BENZETIMIDE Chemical Properties,Uses,Production

Originator

Tremblex,Brocades,Italy,1981

Uses

Anticholinergic.

Definition

ChEBI: Dexetimide is a member of piperidines.

Manufacturing Process

400 parts glacial acetic acid are cooled to 10°C to 20°C. Then there are added first dropwise 300 parts concentrated sulfuric acid followed by portionwise addition of 50 parts dl-1-benzyl-4-(1,3-dicyano-1-phenylpropyl)-piperidine hydrochloride at the same temperature. After the addition is complete, the whole is heated to 125°C in the course of 15 to 20 minutes. This temperature is then maintained for 10 minutes. After cooling, the reaction mixture is poured into ice, alkalized with NH4OH at a temperature < 20°C and extracted with chloroform. The chloroform layer is first washed twice with a K2CO3 5% solution, and then washed twice with water, dried over MgSO4, filtered and evaporated. The residue is dissolved in a mixture of 320 parts acetone and 600 parts diisopropylether, filtered and HCl gas is introduced into the filtrate. The solid hydrochloride is filtered off and dried, to yield 43 parts less pure lbenzyl-4-(2.6-dioxo-3-phenyl-3-piperidyl)-piperidine hydrochloride, melting point 283°C to 294°C.
A sample of 4 parts is recrystallized from a boiling mixture of 80 parts isopropanol, 40 parts methanol and 500 parts water. The whole is filtered and after cooling the filtrate overnight at -20°C, 1-benzyl-4-(2,6-dioxo-3phenyl-3- piperidyl)-piperidine hydrochloride is obtained, melting point 299°C to 301.5°C, as a white amorphous powder.
The dextro-isomer may be separated via the dextro-camphorsulfonate of the base.

Therapeutic Function

Anticholinergic (ophthalmic)

BENZETIMIDE synthesis

14051-33-3
21888-98-2
21888-99-3
Synthesis of BENZETIMIDE from 3-(1-benzyl-4-piperidyl)-3-phenyl-piperidine-2,6-dione

BENZETIMIDE Preparation Products And Raw materials

Raw materials

Hydrochloric acid

Preparation Products

BENZETIMIDE Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28149 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923 1026@dideu.com China 9020 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 50002 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Credit Asia Chemical Co., Ltd. +86 (21) 61124340 China 9767 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29796 68
Nanjing crow LuNing pharmaceutical technology co., LTD 13382066392 CHINA 4880 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Dideu Industries Group Limited 		58
Shaanxi Didu New Materials Co. Ltd 		58
GIHI CHEMICALS CO.,LIMITED 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
LGM Pharma 70
Credit Asia Chemical Co., Ltd. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Nanjing crow LuNing pharmaceutical technology co., LTD 58

View Lastest Price from BENZETIMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BENZETIMIDE USP/EP/BP pictures 2021-07-28 BENZETIMIDE USP/EP/BP
21888-98-2
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

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[3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (S)- Dexbenzetimide Dextrobenzetimide DEXETIMIDE HCL (+)-DEXETIMIDE HYDROCHLORIDE BENZETIMIDE 3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE HYDROCHLORIDE R 16470 (S)-(+)-3-PHENYL-1'-(PHENYLMETHYL)-[3,4'-BIPIPERIDINE]-2,6-DIONE, HCL S(+)-DEXETIMIDE HYDROCHLORIDE S(+)-DEXETIMIDE HYDROCHLORIDE (R16470) H IGH AFFINITY MUSCARI (3S)-3-(1-Benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione (S)-(+)-Dexetimide [3,4'-Bipiperidine]-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, (3S)- BENZETIMIDE USP/EP/BP (+)-Benzetimide RSYYBENZETIMIDE 21888-98-2 21888-96-9